Depletion of hypothalamic norepinephrine reduces the fever induced by polyriboinosinic acid: polyribocytidylic acid (Poly I:Poly C) in rats.

Abstract

Administration of either Poly I:Poly C (0.05-0.50 micrograms) or norepinephrine (2-8 micrograms) into the anterior hypothalamic area produced a dose-related fever in rats. The fever induced by Poly I:Poly C was attenuated after selective depletion of norepinephrine in the hypothalamus. However, selective depletion of hypothalamic norepinephrine did not affect the fever induced by intrahypothalamic norepinephrine. The data indicate that Poly I:Poly C may act to induce fever through the endogenous release of norepinephrine from the rat's hypothalamus.

• Authors: H J Liu, C M Young, M T Lin
• Journal: Experientia (Experientia) Vol. 45 Issue 8 Pg. 720-2 (Aug 15 1989) ISSN: 0014-4754 [Print] Switzerland
• PMID: 2759200 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Hydroxydopamines
• Poly I-C
• Dopamine
• Norepinephrine

Topics

• Animals
• Dopamine (metabolism)
• Fever (chemically induced, metabolism, therapy)
• Hydroxydopamines (pharmacology)
• Hypothalamus (drug effects, metabolism)
• Male
• Norepinephrine (metabolism)
• Poly I-C (pharmacology)
• Rats
• Rats, Inbred Strains