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Very high dose cis-platinum (450 mg/sq m) in an infant with rhabdomyosarcoma.

Abstract
The toxic effects of CDDP, erroneously given at 450 mg/sq m, are described. Life threatening gastrointestinal and myelotoxicity was observed as well as prolonged severe renal tubular acidosis without renal failure. No significant oto (brain-stem evoked responses) or neurotoxicity (EEG, neurologic examination and nerve conduction velocity) was detected indicating major age-related differences in the toxicity of this drug.
AuthorsR Haupt, G Perin, S Dallorso, M L Garré, A Sobrero
JournalAnticancer research (Anticancer Res) 1989 Mar-Apr Vol. 9 Issue 2 Pg. 427-8 ISSN: 0250-7005 [Print] Greece
PMID2751267 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Cisplatin
Topics
  • Cisplatin (poisoning, toxicity)
  • Dose-Response Relationship, Drug
  • Humans
  • Infant
  • Rhabdomyosarcoma (drug therapy)

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