Prevention of the formation of arterial thrombi using different antiplatelet drugs: experimental study in dogs.

Abstract

We have induced the formation of arterial thrombosis in dogs by means of an intima lesion produced by continuous current. The platelets were labeled with 111-In-oxine. Groups of 7 mongrel dogs received treatment for 7 days prior to the trial: Group I, control; Group II, 5 mg/kg body weight/day acetylsalicylic acid; Group III, 20 mg/kg body wt/day acetylsalicylic acid; Group IV, 15 mg/kg body wt/day triflusal + 5 mg/kg body wt/day dipyridamole; Group V, 15 mg/kg body wt/day triflusal; and Group VI, 5 mg/kg body wt/day acetylsalicylic acid + 5 mg/kg body wt/day dipyridamole. The only effective treatment for arterial thrombosis prevention was that employed in Group II (p less than 0.05).

• Authors: M C Escudero-Vela, L Alvarez, V Rodríguez, J H del Moral, I Millán, J L Castillo-Olivares
• Journal: Thrombosis research (Thromb Res) Vol. 54 Issue 3 Pg. 187-95 (May 01 1989) ISSN: 0049-3848 [Print] United States
• PMID: 2749611 (Publication Type: Journal Article)

Chemical References

• Indium Radioisotopes
• Platelet Aggregation Inhibitors
• Salicylates
• triflusal
• Dipyridamole
• Aspirin

Topics

• Animals
• Aspirin (blood, therapeutic use)
• Dipyridamole (therapeutic use)
• Dogs
• Indium Radioisotopes
• Platelet Aggregation Inhibitors (therapeutic use)
• Salicylates (therapeutic use)
• Scintillation Counting
• Thrombosis (prevention & control)