[Tiropramide hydrochloride in the premedication of diagnostic and therapeutic proctosigmoidocolonoscopy (endoscopic polypectomy) and the treatment of colonic diverticulosis].

Abstract

This study was undertaken with a view to assessing the effectiveness and tolerance of tiropramide hydrochloride in the premedication of endoscopic rectosigmoidoscopy. The following were considered for this purpose: 1) speed of execution of the procedure; 2) its tolerance; 3) possible complications. The effectiveness of tiropramide was also examined in uncomplicated diverticular disease: 1) comparison of execution times for rectosigmoidoscopy before and after therapy; 2) the evaluation of the reduction in symptomatology. The patients were subdivided into three groups: 1st group submitted to diagnostic rectosigmoidoscopy; 2nd group submitted to therapeutic rectosigmoidoscopy; 3rd group with diverticular disease. In the first group, execution times were less than 20 minutes in all cases bar 1 and tolerance was good in 27 cases, average in 3. In the second group, times were less than 15 minutes in 6 cases and higher in 4, and tolerance was good in 7 cases and average in 3. In the third group (10 patients), examination execution time was reduced after therapy in 9 cases and in the same number pain symptomatology regressed. Tiropramide proved to be the antispastic of choice in premedication for rectosigmoidoscopy and an effective drug in the treatment of uncomplicated diverticular disease.

• Authors: E De Masi
• Journal: Minerva medica (Minerva Med) Vol. 80 Issue 6 Pg. 587-90 (Jun 1989) ISSN: 0026-4806 [Print] Italy
• Vernacular Title: La tiropramide cloridrato nella premedicazione della rettosigmoidocolonscopia diagnostica e terapeutica (polipectomia endoscopica) e nel trattamento della malattia diverticolare del colon.
• PMID: 2747989 (Publication Type: English Abstract, Journal Article)

Chemical References

• Parasympatholytics
• Tyrosine
• tiropramide

Topics

• Adult
• Colonoscopy
• Diverticulum, Colon (drug therapy)
• Drug Evaluation
• Humans
• Intestinal Polyps (surgery)
• Parasympatholytics (therapeutic use)
• Premedication
• Sigmoidoscopy
• Tyrosine (analogs & derivatives, therapeutic use)