Constitutional C-band polymorphism in lymphocytes from patients with chronic myeloid leukemia.

Abstract

The C-band heterochromatin polymorphism of chromosomes 1, 9, and 16 was studied in lymphocytes from 53 patients with Ph1-positive chronic myeloid leukemia (CML) and 183 control persons. The patients had significantly larger heterochromatic blocks on chromosome 16 (p less than 0.01) and fewer partial inversions of chromosome 9 (p less than 0.05) than the control persons, whereas no differences were found for the symmetry/asymmetry pattern. We suggest that the increased constitutive heterochromatin regions may, via sister chromosome exchange, facilitate homo- or hemizygotization of genes which favor neoplasia development and/or progression.

• Authors: U Kristoffersson, A Bernheim, R Berger, B Nilsson, S Heim, N Mandahl, F Mitelman
• Journal: Hereditas (Hereditas) Vol. 110 Issue 2 Pg. 145-8 ( 1989) ISSN: 0018-0661 [Print] England
• PMID: 2745151 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Heterochromatin

Topics

• Chromosome Aberrations
• Chromosome Banding
• Chromosome Inversion
• Chromosomes, Human, Pair 1 (ultrastructure)
• Chromosomes, Human, Pair 16 (ultrastructure)
• Chromosomes, Human, Pair 9 (ultrastructure)
• Heterochromatin (ultrastructure)
• Humans
• Leukemia, Myelogenous, Chronic, BCR-ABL Positive (genetics)
• Polymorphism, Genetic
• Sister Chromatid Exchange