[A study of ivermectin in the treatment of lymphatic filariasis due to Wuchereria bancrofti var. pacifica in French Polynesia].

Abstract

Forty carriers of 20 or more W. bancrofti var. pacifica per ml were blind administered ivermectin at 50, 100, 150 or 200 mcg/kg doses. The rate of successful treatment was 100% with the 4 dosages. The percentage cure rate and the decrease percentage in the microfilarial count were significantly higher in persons treated with 100, 150 and 200 mcg/kg than in persons treated with 50 mcg/kg. Frequency and intensity of side-reactions were similar to those observed during treatment with DEC; they were more frequent and severe in persons with greatest microfilaremia but did not depend on the dosage. Ivermectin in 100 mcg/kg single-dose, administered once a year, is the best candidate to replace DEC in mass treatments.

• Authors: J Roux, P Perolat, J L Cartel, J P Boutin, Y Sechan, M Larivière, M A Aziz
• Journal: Bulletin de la Societe de pathologie exotique et de ses filiales (Bull Soc Pathol Exot Filiales) Vol. 82 Issue 1 Pg. 72-81 (Jan 1989) France
• Vernacular Title: Etude de l'ivermectine pour le traitement de la filariose lymphatique due à Wuchereria bancrofti var. pacifica en Polynésie française.
• PMID: 2743520 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Ivermectin

Topics

• Adult
• Animals
• Carrier State (drug therapy)
• Elephantiasis, Filarial (drug therapy)
• Filariasis (drug therapy)
• Humans
• Ivermectin (adverse effects, therapeutic use)
• Male
• Polynesia
• Wuchereria