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[Activity of lysosomal hydrolases and renewal of proteins in the rat liver, spleen, and thymus during antigenic stimulation and protein deficiency].

Abstract
Activity of cathepsins B and C was increased 1.8-2-fold in spleen simultaneously with a decrease 3.8-fold in the rate of protein renewal in the tissue lysosomal fraction within 4 days after antigen stimulation of rats, maintained within 45 days on a diet containing 5% of protein. Activation of these thiol-dependent proteinases appears to occur in response to development of immunodepressive conditions and may be related to alterations in the rate of their biosynthesis.
AuthorsA V Vasil'ev, L S Konovalova, K D Pletsityĭ, L G Ponomareva, V A Tutel'ian
JournalVoprosy meditsinskoi khimii (Vopr Med Khim) 1989 Jan-Feb Vol. 35 Issue 1 Pg. 92-5 ISSN: 0042-8809 [Print] Russia (Federation)
Vernacular TitleAktivnost' lizosomal'nykh gidrolaz i obnovlenie belka v pecheni, selezenke i timuse krys pri antigennoĭ stimuliatsii i defitsite belka.
PMID2741402 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Antigens
  • Proteins
  • Hydrolases
  • Dipeptidyl-Peptidases and Tripeptidyl-Peptidases
  • Cathepsin C
  • Cathepsin B
Topics
  • Animals
  • Antigens (immunology)
  • Cathepsin B (metabolism)
  • Cathepsin C
  • Dipeptidyl-Peptidases and Tripeptidyl-Peptidases (metabolism)
  • Half-Life
  • Hydrolases (metabolism)
  • Immunization
  • Liver (metabolism)
  • Lysosomes (enzymology)
  • Male
  • Protein Deficiency (metabolism)
  • Proteins (metabolism)
  • Rats
  • Rats, Inbred Strains
  • Spleen (metabolism)
  • Subcellular Fractions (analysis)
  • Thymus Gland (metabolism)

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