Abstract |
Activity of cathepsins B and C was increased 1.8-2-fold in spleen simultaneously with a decrease 3.8-fold in the rate of protein renewal in the tissue lysosomal fraction within 4 days after antigen stimulation of rats, maintained within 45 days on a diet containing 5% of protein. Activation of these thiol-dependent proteinases appears to occur in response to development of immunodepressive conditions and may be related to alterations in the rate of their biosynthesis.
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Authors | A V Vasil'ev, L S Konovalova, K D Pletsityĭ, L G Ponomareva, V A Tutel'ian |
Journal | Voprosy meditsinskoi khimii
(Vopr Med Khim)
1989 Jan-Feb
Vol. 35
Issue 1
Pg. 92-5
ISSN: 0042-8809 [Print] Russia (Federation) |
Vernacular Title | Aktivnost' lizosomal'nykh gidrolaz i obnovlenie belka v pecheni, selezenke i timuse krys pri antigennoĭ stimuliatsii i defitsite belka. |
PMID | 2741402
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- Antigens
- Proteins
- Hydrolases
- Dipeptidyl-Peptidases and Tripeptidyl-Peptidases
- Cathepsin C
- Cathepsin B
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Topics |
- Animals
- Antigens
(immunology)
- Cathepsin B
(metabolism)
- Cathepsin C
- Dipeptidyl-Peptidases and Tripeptidyl-Peptidases
(metabolism)
- Half-Life
- Hydrolases
(metabolism)
- Immunization
- Liver
(metabolism)
- Lysosomes
(enzymology)
- Male
- Protein Deficiency
(metabolism)
- Proteins
(metabolism)
- Rats
- Rats, Inbred Strains
- Spleen
(metabolism)
- Subcellular Fractions
(analysis)
- Thymus Gland
(metabolism)
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