Effects of benfluron metabolites on glycolysis and level of thiol groups in P388 and Ehrlich ascites cells.

Abstract

The effects of two benfluron metabolites, namely 7-dihydrobenfluron (DBF) and N-oxide of benfluron (NOBF), on the aerobic glycolysis of Ehrlich ascites carcinoma (EAC) and P388 cells were studied. Also their effect on the level of total (T-SH) and nonprotein (NP-SH) thiol groups was investigated. A significant inhibition of aerobic glycolysis in the presence of NOBF was found only in P388 cells. Both metabolites decreased more significantly the level of NP-SH than that of T-SH.

• Authors: M Miko, J Krepelka, M Mĕlka, D Vajdová
• Journal: Neoplasma (Neoplasma) Vol. 36 Issue 3 Pg. 305-15 ( 1989) ISSN: 0028-2685 [Print] Slovakia
• PMID: 2739809 (Publication Type: Journal Article)

Chemical References

• Fluorenes
• Lactates
• Sulfhydryl Compounds
• VUFB 13468
• 7-dihydrobenfluron
• benfluron N-oxide
• Glucose

Topics

• Aerobiosis
• Animals
• Carcinoma, Ehrlich Tumor (metabolism)
• Cell Line
• Fluorenes (metabolism, pharmacology)
• Glucose (metabolism)
• Glycolysis (drug effects)
• Lactates (metabolism)
• Leukemia P388 (metabolism)
• Leukemia, Experimental (metabolism)
• Sulfhydryl Compounds (analysis)
• Tumor Cells, Cultured (drug effects)