Abstract |
Flavone acetic acid (FAA), an antitumour agent currently undergoing clinical trial, has immune-modulatory effects on various cytotoxic cells in mice. Natural killer (NK) cell activity in the spleen was augmented 4 h after FAA treatment, and when spleen cells were cultured with interleukin-2 to induce the production of lymphokine-activated-killer (LAK) cells, higher levels of LAK cell activity were generated by spleen cells from FAA-treated animals than by spleen cells from untreated, control mice. The response to FAA by spleen cells from mice bearing the Colon 38 tumour was compared to that of non-tumour bearers. Activity against NK-sensitive YAC-1 tumour targets was augmented to a similar degree, and no activity against NK-resistant P815 targets was detected. FAA was shown to induce haemorrhagic necrosis in the P815 tumour grown as a subcutaneous solid tumour. Furthermore, haemorrhagic necrosis was induced by FAA on Colon 38 tumours growing in mice which had been depleted of NK activity by treatment with anti-asialo GM-1 antibody. Thus, although NK activity could be involved in the long-term host response to the tumour, it does not appear to be a major determinant of FAA-induced haemorrhagic tumour necrosis.
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Authors | L M Ching, B C Baguley |
Journal | European journal of cancer & clinical oncology
(Eur J Cancer Clin Oncol)
Vol. 25
Issue 5
Pg. 821-8
(May 1989)
ISSN: 0277-5379 [Print] England |
PMID | 2737219
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antineoplastic Agents
- Flavonoids
- flavone acetic acid
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Topics |
- Animals
- Antineoplastic Agents
(pharmacology)
- Cytotoxicity Tests, Immunologic
- Flavonoids
(pharmacology)
- Killer Cells, Natural
(drug effects)
- Mice
- Necrosis
- Spleen
(immunology)
- Tumor Cells, Cultured
(drug effects, pathology)
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