[The effect of prednisone in the development of nephropathy in Schoenlein-Henoch purpura].

Abstract

The authors hospitalized in 1976-1987 39 children with Schönlein-Henoch's purpura who on admission had a normal finding in urine. Of the above patients 28 were given prednisone already at the onset of hospitalization, to 11 prednisone was not administered. Patients with prednisone developed nephropathy in one instance (3.5%), patients without prednisone 6 times (54.5%) which is a significant difference. The average prednisone dose was 1.7 mg per kg body weight per day for an average period of 21 days. Usually for 6-10 days the same dose was administered and then it was gradually reduced.

• Authors: J Buchanec, V Galanda, S Beláková, M Minárik, M Zibolen
• Journal: Ceskoslovenska pediatrie (Cesk Pediatr) Vol. 44 Issue 3 Pg. 145-6 (Mar 1989) ISSN: 0069-2328 [Print] Czech Republic
• Vernacular Title: Ovplyvnenie vzniku nefropatie pri Schönleinovej-Henochovej purpure prednisonom.
• PMID: 2731281 (Publication Type: Journal Article)

Chemical References

• Prednisone

Topics

• Child
• Humans
• IgA Vasculitis (complications, drug therapy)
• Kidney Diseases (etiology, prevention & control)
• Prednisone (therapeutic use)