Recovery in non-vascular locked-in syndrome during treatment with Sinemet.

A case of successful pharmacological therapy of non-vascular locked-in syndrome (LIS) is described. A 22-year-old male experienced aqueductal stenosis following an episode of viral meningitis 11 months prior to admission. A ventriculo-peritoneal shunt was inserted and subsequently revised three times. Following the last procedure, the patient remained mute, quadriplegic and aphagic. There was no change in the patient's status for 9 days. Bromocriptine (2.5 mg daily) was begun and increased to 45 mg daily without any change in PECS scores. It was then tapered and Sinemet (75/300 daily) was begun and increased to 75/750 daily. The PECS scores in all areas rose steadily during the subsequent 6 weeks. Sinemet may be of value in the rehabilitation therapy of non-vascular LIS; serial patient evaluation by a PECS system may facilitate assessment of the response.
AuthorsN Rao, J L Costa
JournalBrain injury (Brain Inj) 1989 Apr-Jun Vol. 3 Issue 2 Pg. 207-11 ISSN: 0269-9052 [Print] ENGLAND
PMID2730978 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Drug Combinations
  • carbidopa, levodopa drug combination
  • Levodopa
  • Carbidopa
  • Activities of Daily Living
  • Carbidopa (administration & dosage)
  • Combined Modality Therapy
  • Drug Combinations (administration & dosage)
  • Humans
  • Levodopa (administration & dosage)
  • Male
  • Meningitis, Viral (complications)
  • Quadriplegia (rehabilitation)

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