[A case of recurrent endometrial cancer (clear cell adenocarcinoma) remarkably responsive to combination chemotherapy containing cisplatin].

Abstract

A 60-year-old woman with recurrent stage II endometrial cancer (clear cell adenocarcinoma) was treated with combination chemotherapy containing cisplatin (CDDP). She had undergone abdominal radical hysterectomy (Okabayashi operation) and pelvic lymph node dissections. Endometrial cancerous tissue infiltrated the cervix and lymph nodes. Six months after the operation, the patient had ascites and dyspnea. She was given 25 mg CDDP intra-abdominally and combination chemotherapy containing CDDP (CAP: CDDP 100 mg, ADR 30 mg, CAP 500 mg) three times intravenously. After an administration of CDDP and combination chemotherapy, the amount of ascites and the serum level of CA 125 decreased remarkably. Although the combination chemotherapy containing CDDP for gynecological malignancy has not been sufficiently evaluated as for ovarian carcinomas, the therapy deserves further evaluation in patients with recurrent of endometrial cancer.

• Authors: S Kitayama, M Iwahashi, M Iwahashi, M Yamoto, R Nakano
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 16 Issue 5 Pg. 2099-101 (May 1989) ISSN: 0385-0684 [Print] Japan
• PMID: 2730095 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Antigens, Tumor-Associated, Carbohydrate
• Doxorubicin
• Cyclophosphamide
• Cisplatin

Topics

• Adenocarcinoma (drug therapy, immunology)
• Antigens, Tumor-Associated, Carbohydrate (analysis)
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Cisplatin (administration & dosage)
• Cyclophosphamide (administration & dosage)
• Doxorubicin (administration & dosage)
• Female
• Humans
• Middle Aged
• Neoplasm Recurrence, Local (drug therapy, immunology)
• Remission Induction
• Uterine Neoplasms (drug therapy, immunology)