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Rapid cytoreduction in acute leukemia. Management of cerebral leukostasis by cell pheresis.

Abstract
A patient with acute myelogenous leukemia and symptoms of cerebral leukostasis failed to respond to initial chemotherapy. Reduction in blast count from 220,000/microliter to 40,000/microliter was accomplished over a five hour period by leukapheresis using an intermittent flow cell separator, and symptomatic improvement was dramatic. The technique is simple and rapidly effective and may prove a useful adjunct in the treatment of patients with acute leukemia and high blast counts.
AuthorsR S Eisenstaedt, E M Berkman
JournalTransfusion (Transfusion) 1978 Jan-Feb Vol. 18 Issue 1 Pg. 113-5 ISSN: 0041-1132 [Print] United States
PMID272799 (Publication Type: Case Reports, Journal Article)
Topics
  • Aged
  • Cerebrovascular Circulation
  • Female
  • Humans
  • Leukemia, Myeloid, Acute (blood, therapy)
  • Plasmapheresis

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