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Bacterial osteomyelitis. Adjunctive hyperbaric oxygen therapy.

Abstract
Mechanistically, hyperbaric oxygen (HBO) appears useful for the treatment of osteomyelitis. HBO increases the oxygen tension in infected tissue, including bone. An adequate oxygen tension is necessary for oxygen-dependent killing of organisms by polymorphonuclear leukocytes, and for fibroblast activity leading to angiogenesis and wound healing. In addition, HBO augments the killing of Pseudomonas aeruginosa by the aminoglycoside tobramycin. At the University of Texas Medical Branch in Galveston, adjunctive HBO is used for Cierny-Mader stage 3B and 4B osteomyelitis.
AuthorsJ T Mader, C A Hicks, J Calhoun
JournalOrthopaedic review (Orthop Rev) Vol. 18 Issue 5 Pg. 581-5 (May 1989) ISSN: 0094-6591 [Print] United States
PMID2726292 (Publication Type: Journal Article)
Topics
  • Bacterial Infections (therapy)
  • Humans
  • Hyperbaric Oxygenation
  • Osteomyelitis (therapy)

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