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In vitro modulation of lymphocyte proliferation by prednisolone and interferon-alpha in patients with HTLV-I-associated myelopathy (HAM).

Abstract
One of the hallmarks of human T-lymphotropic virus type I (HTLV-I) infection is the proliferation in vitro of peripheral blood lymphocytes (PBLs) in the absence of growth factors. This phenomenon, the autologous proliferative response (APR), involves spontaneous growth of HTLV-I-infected T-cells and proliferation of T-cells in response to the infected cells. We studied the modulating effect of prednisolone (PSL) and interferon-alpha (IFN) on APR of PBLs obtained from five patients with HTLV-I-associated myelopathy (HAM). APR was significantly inhibited by PSL and IFN suggesting that APR is important in the pathogenesis of HAM.
AuthorsS Ijichi, N Eiraku, M Osame, S Izumo, R Kubota, I Maruyama, M Matsumoto, S Sonoda
JournalJournal of neuroimmunology (J Neuroimmunol) Vol. 23 Issue 2 Pg. 175-8 (Jul 1989) ISSN: 0165-5728 [Print] Netherlands
PMID2723044 (Publication Type: Journal Article)
Chemical References
  • Interferon Type I
  • Prednisolone
Topics
  • Adult
  • Aged
  • Cell Division (drug effects)
  • Female
  • HTLV-I Infections (complications)
  • Humans
  • Interferon Type I (pharmacology)
  • Lymphocytes (pathology)
  • Middle Aged
  • Prednisolone (pharmacology)
  • Spinal Cord Diseases (blood, etiology, pathology)

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