Abstract |
One of the hallmarks of human T-lymphotropic virus type I ( HTLV-I) infection is the proliferation in vitro of peripheral blood lymphocytes (PBLs) in the absence of growth factors. This phenomenon, the autologous proliferative response (APR), involves spontaneous growth of HTLV-I-infected T-cells and proliferation of T-cells in response to the infected cells. We studied the modulating effect of prednisolone (PSL) and interferon-alpha (IFN) on APR of PBLs obtained from five patients with HTLV-I-associated myelopathy (HAM). APR was significantly inhibited by PSL and IFN suggesting that APR is important in the pathogenesis of HAM.
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Authors | S Ijichi, N Eiraku, M Osame, S Izumo, R Kubota, I Maruyama, M Matsumoto, S Sonoda |
Journal | Journal of neuroimmunology
(J Neuroimmunol)
Vol. 23
Issue 2
Pg. 175-8
(Jul 1989)
ISSN: 0165-5728 [Print] Netherlands |
PMID | 2723044
(Publication Type: Journal Article)
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Chemical References |
- Interferon Type I
- Prednisolone
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Topics |
- Adult
- Aged
- Cell Division
(drug effects)
- Female
- HTLV-I Infections
(complications)
- Humans
- Interferon Type I
(pharmacology)
- Lymphocytes
(pathology)
- Middle Aged
- Prednisolone
(pharmacology)
- Spinal Cord Diseases
(blood, etiology, pathology)
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