A comparison of cefmetazole, and cefoxitin for the treatment of patients hospitalized with acute urinary tract infections.

Abstract

This study evaluates the safety and efficacy of cefmetazole in comparison with cefoxitin in the parenteral treatment of patients hospitalized with acute urinary tract infections. Of the 49 evaluable patients, 27 were randomized to cefmetazole and 22 to cefoxitin. There was clinical success in 26 (96%) patients and bacteriological cure in 22 (81%) patients receiving cefmetazole. This compares with clinical success in 21 (95%) patients and bacteriological cure in 17 (77%) patients randomized to cefoxitin. There were no adverse reactions associated with either antibiotic. This study indicates that the clinical and bacteriological outcome was similar.

• Authors: B M Burke, D L Kessler, C Cirulli, R B Bracken
• Journal: The Journal of antimicrobial chemotherapy (J Antimicrob Chemother) Vol. 23 Suppl D Pg. 35-8 (Apr 1989) ISSN: 0305-7453 [Print] England
• PMID: 2722722 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Cefmetazole
• Cefoxitin

Topics

• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Cefmetazole (adverse effects, therapeutic use)
• Cefoxitin (adverse effects, therapeutic use)
• Female
• Humans
• Injections, Intravenous
• Male
• Middle Aged
• Random Allocation
• Urinary Tract Infections (drug therapy, microbiology)