Clear-cell syringoma. Immunohistochemistry and electron microscopy study.

Abstract

Clear-cell syringoma is a histologic variant of syringoma that is otherwise clinically indistinguishable from ordinary syringoma. This variant is formed by cells that have pale or clear cytoplasm as a result of glycogen accumulation. There is a high association of clear-cell syringoma and diabetes mellitus. A case of clear-cell syringoma associated with diabetes mellitus is described. Electron microscopic examination revealed that periluminal cells showed intra- and extracytoplasmic multivesicular bodies that may be characteristic of the clear-cell variant. Immunohistochemistry for carcinoembryonic antigen (CEA) showed ordinary syringomas as in the presence of CEA within and surrounding duct-like spaces.

• Authors: P Ambrojo, L Requena Caballero, A Aguilar Martínez, E Sánchez Yus, V Furió
• Journal: Dermatologica (Dermatologica) Vol. 178 Issue 3 Pg. 164-6 ( 1989) ISSN: 0011-9075 [Print] Switzerland
• PMID: 2721807 (Publication Type: Case Reports, Journal Article)

Chemical References

• Carcinoembryonic Antigen

Topics

• Adenoma (analysis, ultrastructure)
• Aged
• Carcinoembryonic Antigen (analysis)
• Cytoplasm (ultrastructure)
• Cytoplasmic Granules (ultrastructure)
• Epithelium (ultrastructure)
• Eyelid Neoplasms (analysis, ultrastructure)
• Female
• Humans
• Immunohistochemistry
• Microscopy, Electron
• Sweat Gland Neoplasms (analysis, ultrastructure)