[Electron microscopic study of Darier's follicular dyskeratosis].

Abstract

Ultrastructure of the skin biopsy specimens of 10 patients with Darier's keratosis follicularis (DKF), 6 of them with the vesicular form of the dermatosis, has been examined by electron microscopy. The study has revealed dyskeratosis with tonofilament homogenization and well-developed keratohyalin granules, round bodies and granules, and acantholysis less manifest than in Hailey-Hailey's chronic benign familial pemphigus. Ultrastructural features of the skin in vesicular DKF present as acantholysis and dyskeratosis more manifest than in typical DKF. Similarity of the morphologic signs of the typical and vesicular DKF permit considering the vesicular form of this keratosis as one of DKF variants.

• Authors: Z M Getling, I A Chistiakova
• Journal: Vestnik dermatologii i venerologii (Vestn Dermatol Venerol) Issue 1 Pg. 14-7 ( 1989) ISSN: 0042-4609 [Print] Russia (Federation)
• Vernacular Title: Elektronno-mikroskopicheskoe issledovanie follikuliarnogo diskeratoza Dar'e.
• PMID: 2718611 (Publication Type: English Abstract, Journal Article)

Topics

• Adolescent
• Adult
• Biopsy
• Chronic Disease
• Darier Disease (pathology)
• Epidermis (ultrastructure)
• Female
• Humans
• Male
• Microscopy, Electron