Kinetics of antipyrine and sulfamethazine in patients recovered from dihydralazine-hepatitis.

Abstract

Pharmacokinetic studies with sulfamethazine (500 mg) and antipyrine (15 mg/kg) were performed in 27 hypertonic patients (16 females, 11 males, 37-78 years) who had recovered from a dihydralazine-induced hepatitis, and 21 patients with essential hypertension (13 females, 8 males, 18-74 years) treated with antihypertonics excluding dihydralazine. 20 patients of the hepatitis group (74%) and 12 patients of the control group (57%) were slow acetylators. With regard to the pharmacokinetic parameters no differences were found in both slow and rapid acetylators between the sulfamethazine group and the antipyrine group.

• Authors: W Siegmund, G Franke, R Baumgarten, J D Fengler, R Krüger, R Reichardt
• Journal: International journal of clinical pharmacology, therapy, and toxicology (Int J Clin Pharmacol Ther Toxicol) Vol. 27 Issue 4 Pg. 165-9 (Apr 1989) ISSN: 0174-4879 [Print] Germany
• PMID: 2714917 (Publication Type: Journal Article)

Chemical References

• Hydralazine
• Sulfamethazine
• Dihydralazine
• Antipyrine

Topics

• Acetylation
• Adult
• Aged
• Antipyrine (pharmacokinetics)
• Chemical and Drug Induced Liver Injury (metabolism)
• Dihydralazine (adverse effects)
• Female
• Humans
• Hydralazine (analogs & derivatives)
• Male
• Middle Aged
• Oxidation-Reduction
• Sulfamethazine (pharmacokinetics)