Antibiotic-metal interactions in saline medium.

Abstract	The commonly used surgical alloys, stainless steel, titanium and Vitallium, were exposed to normal saline solution containing antibiotics frequently used for the control and treatment of orthopaedic infections and the corrosion potential versus time behaviour was followed. It was found that only one antibiotic, oxytetracycline, exerted a significant effect on electrochemical behaviour, producing an anodic shift of 120-250 mV in the Ecorr of the three metals. The study indicated that oxytetracycline at addition levels of 0.01-1.0 mg/ml acts as an anodic corrosion inhibitor.
Authors	J A von Fraunhofer, N Berberich, D Seligson
Journal	Biomaterials (Biomaterials) Vol. 10 Issue 2 Pg. 136-8 (Mar 1989) ISSN: 0142-9612 [Print] Netherlands
PMID	2706303 (Publication Type: Journal Article)
Chemical References	Chromium Alloys Stainless Steel Vitallium Titanium Oxytetracycline
Topics	Chromium Alloys Corrosion Humans Oxytetracycline (therapeutic use) Stainless Steel Surgical Wound Infection (prevention & control) Titanium Vitallium

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