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Vitamin E, immune response, and disease resistance.

Abstract
Vitamin E as a dietary supplement or as part of an adjuvant vaccine formulation increases humoral and cell-mediated immunity and disease resistance in laboratory animals, farm animals, and humans. Adjuvant administration has far greater effect than dietary supplementation. Vitamin E as an antioxidant protects the cells of the immune response from peroxidative damage; possibly through a modulation of lipoxygenation of arachidonic acid, vitamin E alters cell membrane functions and cell-cell interactions. The most pronounced effect of vitamin E is on immune phagocytosis. Dietary supplementation is beneficial to animals, especially under stress, in decreasing susceptibility to infections. Vitamin E adjuvant vaccines have provided greater immunoprotection against enterotoxemia and epididymitis in sheep than conventional vaccines.
AuthorsR P Tengerdy
JournalAnnals of the New York Academy of Sciences (Ann N Y Acad Sci) Vol. 570 Pg. 335-44 ( 1989) ISSN: 0077-8923 [Print] United States
PMID2698109 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
Chemical References
  • Adjuvants, Immunologic
  • Vitamin E
Topics
  • Adjuvants, Immunologic
  • Animals
  • Antibody Formation (physiology)
  • Diet
  • Humans
  • Immunity (physiology)
  • Immunity, Cellular (physiology)
  • Immunity, Innate (physiology)
  • Vitamin E (administration & dosage, physiology)

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