Abstract |
Vitamin E as a dietary supplement or as part of an adjuvant vaccine formulation increases humoral and cell-mediated immunity and disease resistance in laboratory animals, farm animals, and humans. Adjuvant administration has far greater effect than dietary supplementation. Vitamin E as an antioxidant protects the cells of the immune response from peroxidative damage; possibly through a modulation of lipoxygenation of arachidonic acid, vitamin E alters cell membrane functions and cell-cell interactions. The most pronounced effect of vitamin E is on immune phagocytosis. Dietary supplementation is beneficial to animals, especially under stress, in decreasing susceptibility to infections. Vitamin E adjuvant vaccines have provided greater immunoprotection against enterotoxemia and epididymitis in sheep than conventional vaccines.
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Authors | R P Tengerdy |
Journal | Annals of the New York Academy of Sciences
(Ann N Y Acad Sci)
Vol. 570
Pg. 335-44
( 1989)
ISSN: 0077-8923 [Print] United States |
PMID | 2698109
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
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Chemical References |
- Adjuvants, Immunologic
- Vitamin E
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Topics |
- Adjuvants, Immunologic
- Animals
- Antibody Formation
(physiology)
- Diet
- Humans
- Immunity
(physiology)
- Immunity, Cellular
(physiology)
- Immunity, Innate
(physiology)
- Vitamin E
(administration & dosage, physiology)
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