[The experimental use of surfagon, a synthetic analog of luliberin, in follicular ovarian cysts].

Abstract

The use of a synthetic peptide analog of LH-RH agonist--[D-Ala6, des Gly10, Pro9]-LH-RH ethylamide (surfagon) at microdoses and in short courses returned to normal the ovulatory cycle in the anovulatory condition in rats and caused luteinization of follicular cysts in rats and cows with further normalization of ovarian function. It is assumed that surfagon will be effective for the treatment of anovulatory condition and ovarian follicular cysts in women.

• Authors: O G Krivosheev, V Ia Chernykh, V A Vinogradov, N A Nabatchikova, E A Siutkin
• Journal: Problemy endokrinologii (Probl Endokrinol (Mosk)) 1989 Nov-Dec Vol. 35 Issue 6 Pg. 54-8 ISSN: 0375-9660 [Print] Russia (Federation)
• Vernacular Title: Primenenie surfagona, sinteticheskogo analoga liuliberina, pri follikuliarnykh kistakh iaichnikov v éksperimente.
• PMID: 2695918 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Hormones
• Gonadotropin-Releasing Hormone
• surfagon
• Luteinizing Hormone
• Dinoprost

Topics

• Animals
• Anovulation (drug therapy, etiology)
• Cattle
• Cattle Diseases (drug therapy)
• Dinoprost (therapeutic use)
• Drug Evaluation, Preclinical (veterinary)
• Female
• Follicular Cyst (drug therapy, etiology, veterinary)
• Gonadotropin-Releasing Hormone (analogs & derivatives, therapeutic use)
• Hormones (therapeutic use)
• Luteinizing Hormone (blood)
• Ovarian Cysts (drug therapy, etiology, veterinary)
• Ovariectomy
• Ovary (pathology)
• Rats
• Rats, Inbred Strains