Abstract |
It is important to understand the distribution of steroidogenesis in steroid producing tissues in order to obtain a better understanding of steroid metabolism. Recent advances in purification and subsequent generation of antibodies against cytochromes P-450 specific for steroid hormone biosynthesis have made it possible to localize the sites of steroidogenesis immunohistochemically. This review provides the localization of sex-steroid hormone biosynthesis in normal and pathological human ovaries including sex-cord stromal tumors, hyperthecosis and Brenner tumor, as determined by the tissue distribution of immunoreactivity of individual enzymes specific for different stages of the biosynthetic process.
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Authors | H Sasano, N Sasano |
Journal | Pathology, research and practice
(Pathol Res Pract)
Vol. 185
Issue 6
Pg. 942-8
(Dec 1989)
ISSN: 0344-0338 [Print] Germany |
PMID | 2694125
(Publication Type: Journal Article, Review)
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Chemical References |
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Topics |
- Female
- Humans
- Immunohistochemistry
(methods)
- Ovarian Neoplasms
(metabolism, pathology)
- Ovary
(cytology, metabolism)
- Steroids
(metabolism)
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