Italian multicenter study on the treatment of chronic obstructive lung disease with bromhexine. A double-blind placebo-controlled trial.

Abstract

237 out-patients suffering from chronic obstructive lung disease (COLD) were selected from 7 Italian clinical centers. They were randomly allocated to either placebo or bromhexine 30 mg b.i.d. p.o., in a double-blind fashion. Sputum volume and quality, facility of expectoration, cough, dyspnea, auscultatory thoracic symptoms, forced expiratory volume, peak expiratory flow rate and residual volume were evaluated. Bromhexine showed a statistically significant therapeutic activity in comparison to placebo. This action was rapid, marked and effective in determining a modulation of bronchial secretions.

• Authors: S Valenti, G Marenco
• Journal: Respiration; international review of thoracic diseases (Respiration) Vol. 56 Issue 1-2 Pg. 11-5 ( 1989) ISSN: 0025-7931 [Print] Switzerland
• PMID: 2690235 (Publication Type: Clinical Trial, Journal Article, Multicenter Study, Randomized Controlled Trial)

Chemical References

• Bromhexine

Topics

• Adult
• Aged
• Bromhexine (therapeutic use)
• Double-Blind Method
• Female
• Humans
• Italy
• Lung Diseases, Obstructive (drug therapy)
• Male
• Middle Aged
• Multicenter Studies as Topic
• Peak Expiratory Flow Rate (drug effects)
• Randomized Controlled Trials as Topic
• Residual Volume (drug effects)
• Sputum (drug effects, metabolism)