[In vivo sensitivity of Plasmodium falciparum to piperaquine phosphate assayed in Linshui and Baisha counties, Hainan Province].

Abstract

Fifty-three cases of falciparum malaria in Linshui County, Baisha County and Sanya Municipality were treated with piperaquine phosphate at a total dose of 1.5g base over 3 days in July to December, 1986. The mean defervescence time was 36 +/- 20.7h; the mean asexual parasite clearance time was 69.7 +/- 20.9h. At 14-28d follow-up recrudescence was observed with asexual parasitemia in 7 of the 47 cases, showing RI resistance to piperaquine. Gametocytemia was positive in 35 cases (74.5%) during the follow-up period.

• Authors: C X Lan, X Lin, Z S Huang, Y S Chen, R N Guo
• Journal: Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases (Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi) Vol. 7 Issue 3 Pg. 163-5 ( 1989) ISSN: 1000-7423 [Print] China
• PMID: 2686856 (Publication Type: English Abstract, Journal Article)

Chemical References

• Antimalarials
• Quinolines
• piperaquine

Topics

• Adolescent
• Adult
• Animals
• Antimalarials (pharmacology, therapeutic use)
• Child
• Child, Preschool
• China
• Drug Resistance
• Female
• Humans
• Malaria (drug therapy)
• Male
• Middle Aged
• Plasmodium falciparum (drug effects)
• Quinolines (pharmacology, therapeutic use)