Pain relief following herniotomy: a double-blind randomized comparison between naproxen and placebo.

Abstract

Sixty consecutive out-patients were randomly assigned to have either a non-steroid anti-inflammatory drug (naproxen 500 mg) or an identical placebo administered as suppositories half an hour before unilateral herniotomy. Within 1.5 h after the end of surgery, pain scores were significantly improved in patients receiving naproxen (P less than 0.02). The long-term analgesic effect was measured indirectly by registering the postoperative requirement for supplementary analgesic doses of acetylsalicylic acid 1 g plus codeine 20 mg. The time elapsing before the first demand for additional analgesics was prolonged by median 1.5 h, and the need for further analgesic treatment during 24 h was significantly reduced (P less than 0.003) in the naproxen group (median, 2 doses) compared to the placebo group (median, 4 doses). No statistically significant difference was found between the groups with regard to the occurrence of side-effects.

• Authors: S Dueholm, M Forrest, E Hjortsø, E Lemvigh
• Journal: Acta anaesthesiologica Scandinavica (Acta Anaesthesiol Scand) Vol. 33 Issue 5 Pg. 391-4 (Jul 1989) ISSN: 0001-5172 [Print] England
• PMID: 2678876 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Suppositories
• Naproxen

Topics

• Adolescent
• Adult
• Aged
• Double-Blind Method
• Female
• Hernia, Inguinal (surgery)
• Herniorrhaphy
• Humans
• Male
• Middle Aged
• Naproxen (administration & dosage, therapeutic use)
• Pain, Postoperative (drug therapy)
• Randomized Controlled Trials as Topic
• Suppositories