Erythema elevatum diutinum: an ultrastructural case study.

Abstract

An electron microscopic study was made of a patient with erythema elevatum diutinum, a rare variant of cutaneous leukocytoclastic vasculitis. Biopsies were obtained from early evolving and late fibroproliferative lesions. Early lesions showed vasculitis and a massive dermal infiltrate composed mainly of neutrophils, histiocytes/macrophages and apparently increased Langerhans cells. Later lesions were characterized by a dense fibrosis with a proliferation of fibroblasts and myofibroblasts and a dermal infiltrate in which lymphocytes and histiocytes/macrophages predominated. Even in later lesions, dermal Langerhans cells were observed in great number. Langerhans cells may be involved in the evolution of this rare disease.

• Authors: A Y Lee, H Nakagawa, T Nogita, Y Ishibashi
• Journal: Journal of cutaneous pathology (J Cutan Pathol) Vol. 16 Issue 4 Pg. 211-7 (Aug 1989) ISSN: 0303-6987 [Print] United States
• PMID: 2677070 (Publication Type: Case Reports, Journal Article)

Chemical References

• Nerve Growth Factors
• S100 Calcium Binding Protein beta Subunit
• S100 Proteins

Topics

• Erythema (pathology)
• Fibrosis
• Humans
• Immunoenzyme Techniques
• Langerhans Cells (pathology)
• Male
• Microscopy, Electron
• Middle Aged
• Nerve Growth Factors
• S100 Calcium Binding Protein beta Subunit
• S100 Proteins (analysis)
• Skin (ultrastructure)