[In vitro and in vivo activity of a combination of clavulanic acid and amoxicillin against Klebsiella pneumoniae producing extended broad-spectrum betalactamase (CTX-1, SHV-3, SHV-4)].

Abstract

In vitro activity of an aminopenicillin (amoxicillin or ampicillin) combined with a betalactamase inhibitor (clavulanic acid or sulbactam, 2 mg/l) was examined against 39 strains of K. pneumoniae producing 3 types of extended broad spectrum betalactamases (CTX-1, SHV-3, SHV-4). Clavulanic acid produces the best synergistic effect. The in vivo activity of Augmentin (amoxicillin + clavulanic acid), 1 g once or twice a day, during 10 +/- 3 days was evaluated on 10 cases urinary tract infections in paraplegic patients. After 3 days, no leucocyturia was observed and bacteria were no more detected. The inhibitory effect of clavulanic acid for the extended broad-spectrum betalactamases shows that such an association could be probably chosen as well for treatment urinary infection.

• Authors: M L Migueres, E Ronco, M Guenounou, A Philippon
• Journal: Pathologie-biologie (Pathol Biol (Paris)) Vol. 37 Issue 5 Pg. 397-401 (May 1989) ISSN: 0369-8114 [Print] France
• Vernacular Title: Activité in vitro et in vivo de l'association acide clavulanique - amoxicilline chez Klebsiella pneumoniae productrice de bêtalactamase à spectre élargi (CTX-1, SHV-3, SHV-4).
• PMID: 2674869 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Clavulanic Acids
• beta-Lactamase Inhibitors
• Ampicillin
• Amoxicillin
• beta-Lactamases
• Sulbactam

Topics

• Amoxicillin (pharmacology, therapeutic use)
• Ampicillin (pharmacology)
• Clavulanic Acids (pharmacology, therapeutic use)
• Drug Therapy, Combination (pharmacology, therapeutic use)
• Humans
• In Vitro Techniques
• Isoelectric Point
• Klebsiella pneumoniae (drug effects, enzymology)
• Sulbactam (pharmacology)
• Urinary Tract Infections (drug therapy)
• beta-Lactamase Inhibitors
• beta-Lactamases (metabolism)