[In vitro and in vivo activity of a combination of clavulanic acid and amoxicillin against Klebsiella pneumoniae producing extended broad-spectrum betalactamase (CTX-1, SHV-3, SHV-4)].

In vitro activity of an aminopenicillin (amoxicillin or ampicillin) combined with a betalactamase inhibitor (clavulanic acid or sulbactam, 2 mg/l) was examined against 39 strains of K. pneumoniae producing 3 types of extended broad spectrum betalactamases (CTX-1, SHV-3, SHV-4). Clavulanic acid produces the best synergistic effect. The in vivo activity of Augmentin (amoxicillin + clavulanic acid), 1 g once or twice a day, during 10 +/- 3 days was evaluated on 10 cases urinary tract infections in paraplegic patients. After 3 days, no leucocyturia was observed and bacteria were no more detected. The inhibitory effect of clavulanic acid for the extended broad-spectrum betalactamases shows that such an association could be probably chosen as well for treatment urinary infection.
AuthorsM L Migueres, E Ronco, M Guenounou, A Philippon
JournalPathologie-biologie (Pathol Biol (Paris)) Vol. 37 Issue 5 Pg. 397-401 (May 1989) ISSN: 0369-8114 [Print] FRANCE
Vernacular TitleActivité in vitro et in vivo de l'association acide clavulanique - amoxicilline chez Klebsiella pneumoniae productrice de bêtalactamase à spectre élargi (CTX-1, SHV-3, SHV-4).
PMID2674869 (Publication Type: Comparative Study, English Abstract, Journal Article)
Chemical References
  • Clavulanic Acids
  • beta-Lactamase Inhibitors
  • Ampicillin
  • Amoxicillin
  • beta-Lactamases
  • Sulbactam
  • Amoxicillin (pharmacology, therapeutic use)
  • Ampicillin (pharmacology)
  • Clavulanic Acids (pharmacology, therapeutic use)
  • Drug Therapy, Combination (pharmacology, therapeutic use)
  • Humans
  • In Vitro Techniques
  • Isoelectric Point
  • Klebsiella pneumoniae (drug effects, enzymology)
  • Sulbactam (pharmacology)
  • Urinary Tract Infections (drug therapy)
  • beta-Lactamase Inhibitors
  • beta-Lactamases (metabolism)

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