Improvement of tear lysosomal enzyme levels after treatment with bone marrow transplantation in a patient with I-cell disease.

Abstract

We examined the lysosomal enzyme levels in tear fluids from a patient with I-cell disease after treatment by bone marrow transplantation. Acid phosphatase, beta-D-glucuronidase, N-acetyl-beta-D-glucosaminidase, alpha-L-fucosidase and alpha-D-mannosidase activities were reduced to normal or nearly normal levels after the treatment. We believe that the measurement of tear enzyme levels in I-cell disease is useful for knowing the efficacy of the bone marrow transplantation.

• Authors: K Yamaguchi, S Hayasaka, S Hara, I Kurobane, K Tada
• Journal: Ophthalmic research (Ophthalmic Res) Vol. 21 Issue 3 Pg. 226-9 ( 1989) ISSN: 0030-3747 [Print] Switzerland
• PMID: 2674824 (Publication Type: Case Reports, Journal Article)

Topics

• Bone Marrow Transplantation
• Female
• Humans
• Infant
• Lysosomes (enzymology)
• Mucolipidoses (enzymology, surgery)
• Tears (enzymology)
• Time Factors