Abstract |
Patients with insulin-dependent diabetes mellitus ( IDDM) and non-proliferative retinopathy were randomized to intensified conventional insulin treatment (ICT, n = 44) or regular treatment (RT, n = 51). During a 3-year period the glycosylated haemoglobin (HbA1c) levels were reduced to a greater extent (P = 0.00001) in the ICT group (from 9.5 +/- 0.2 to 7.4%, P = 0.0001) than in the RT group (9.4 +/- 0.2 to 9.0 +/- 0.2, P = 0.004). The urinary albumin excretion rate (UAER) increased significantly (P = 0.033) in the RT group but not in the ICT group, and the UAER differed significantly (P = 0.031) between the groups after 3 years. The mean HbA1c values during the study period independently influenced the deterioration of UAER levels (P = 0.029). Initial diastolic blood pressure (P = 0.112), the HbA1c value at entry (P = 0.480) and the smoking habits (P = 0.959) were not related to change of UAER levels. Manifest nephropathy after 3 years was seen almost exclusively in patients with HbA1c levels above 9%. Improved blood glucose control, without 'near normoglycaemia', delayed the progression of nephropathy in patients with IDDM and retinopathy.
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Authors | P Reichard, U Rosenqvist |
Journal | Journal of internal medicine
(J Intern Med)
Vol. 226
Issue 2
Pg. 81-7
(Aug 1989)
ISSN: 0954-6820 [Print] England |
PMID | 2671247
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Adult
- Albuminuria
- Blood Glucose
(analysis)
- Diabetes Mellitus, Type 1
(blood, drug therapy)
- Diabetic Nephropathies
(prevention & control)
- Diabetic Retinopathy
(complications)
- Female
- Glomerular Filtration Rate
- Humans
- Hypertension
(complications)
- Insulin
(administration & dosage)
- Male
- Random Allocation
- Risk Factors
- Smoking
(adverse effects)
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