[Survival outcome comparative analysis of Liver transplantation and radical resection surgery for Klatskin tumor].

Abstract

OBJECTIVE:

To compare the survival results of liver transplantation with radical resection for klatskin tumor based on the published literatures.

METHODS:

We retrieved Medline for articles on treatment of klatskin tumor published from January 1996 to December 2014, and choose the literatures including liver transplantation and radical resection. Review Manager 5. 0 software was used to perform the Meta-analysis of the extracted data.

RESULTS:

After performing meta-analysis of 11 studies including 676 patients, we found comparable patient survival rate between liver transplantation group and radical resection group (1-year RR:1. 00, 95% CI:0. 82 - 1. 23, P = 0. 97; 3-year RR:1. 15, 95% CI:0. 75 - 1. 77, P 0. 51, 5-year RR: 1. 37, 95% CI: 0. 74 - 2. 53, P = 0. 32, respectively). No statistical significance of overall survival rate were shown between this 2 groups whether in short-term or long-time, but the total survival trends show the long-time survival of LT group is better than that of RR group which has the potential longer survival time.

CONCLUSIONS:

Liver transplantation was equivalent to radical resection for klatskin tumor treatment in terms of patient survival, with potential higher long-term patient survival rate and lower recurrence. especially for the patients with unrespectable KT or insufficient liver function, LT is superior for clinical outcome.

• Authors: Furong Liu, Yueming Lin, Xiaoshun He, Cheng Zhang, Yi Ma, Xiaofeng Zhu, Guodong Wang, Anbin Hu
• Journal: Zhonghua yi xue za zhi (Zhonghua Yi Xue Za Zhi) Vol. 95 Issue 26 Pg. 2109-13 (Jul 14 2015) ISSN: 0376-2491 [Print] China
• PMID: 26710876 (Publication Type: Comparative Study, Journal Article)

Topics

• Bile Duct Neoplasms
• Humans
• Klatskin Tumor
• Liver Transplantation
• Survival Rate