Abstract | BACKGROUND AND AIMS: MATERIAL AND METHODS: In a prospective double-blind randomized controlled trial, a total of 240 patients, American Society of Anesthesiologists physical status Class I and II, scheduled for elective surgery were randomly assigned into two equally sized groups (n = 120). Patients in Group A received low dose of propofol (10 mg) and patients in Group B received the same volume of normal saline (control group). Two minutes later, all patients were given fentanyl (2 μg/kg) over 2 s through the peripheral IV line in the forearm. The vital sign profiles and frequency and intensity of cough were recorded within 2 min after fentanyl bolus by a nurse blinded to study design. Data were analyzed using independent t-test, paired t-test and Chi-square test. RESULTS: The incidences of FIC were 9.2% and 40.8% in Group A ( propofol) and Group B (placebo) respectively (P = 0.04). Furthermore, there was a significant difference in the intensity of cough between Groups A and B (P < 0.0001). The hemodynamic value (systolic blood pressure, diastolic blood pressure, heart rate, mean arterial pressure and saturation of oxygen) were similar, and there was no significant difference between two groups in the baseline value or after propofol or placebo injection.
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Authors | Abolfazl Firouzian, Seyed Abdollah Emadi, Afshin Gholipour Baradari, Robabeh Mousavi, Alieh Zamani Kiasari |
Journal | Journal of anaesthesiology, clinical pharmacology
(J Anaesthesiol Clin Pharmacol)
2015 Oct-Dec
Vol. 31
Issue 4
Pg. 522-5
ISSN: 0970-9185 [Print] India |
PMID | 26702212
(Publication Type: Journal Article)
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