In about 10% of patients operated on a chronic
sinusitis, an aspergilloma is found in the paranasal sinus. To detect possible underlying immunodeficiencies, patients with aspergilloma were subjected to an immunological screening programme. The data were compared with those of patients suffering from non-mycotic chronic
sinusitis and healthy controls. Totale lymphocyte counts and immunological levels were normal in both groups of
sinusitis. Leukocyte subset analyses by membrane fluorescence revealed a significant decrease of CD11+ cells, i.e. macrophages/monocytes and NK cells, in both types of
sinusitis. Furthermore, a markedly enhanced frequency of CD25+-cells, i.e. IL 2-receptor bearing cells, was observed in patients with aspergilloma. Peripheral blood lymphocytes of both groups of patients showed a significant reduction in the proliferative response to both T and B-cell
mitogens, the values for the
mitogens ConA and PWM being significantly lower in aspergilloma patients than in those with non-mycotic
sinusitis. This lack of lymphocyte stimulation in the aspergilloma group was also manifest in skin tests to recall
antigens. These first data suggest an immunodeficiency in association with chronic
sinusitis caused by Aspergillus fumigatus. Further studies are needed to clarify if this defect is cause or result of the mycotic
infection.