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The Epidemiology of Male Breast Cancer.

Abstract
Male breast cancer is a rare disease, accounting for only 1% of breast cancer diagnoses in the USA. The current literature suggests that genetic factors including BRCA2 mutations, family history, age, androgen/estrogen imbalance, and environmental exposures may predispose to male breast cancer. In this manuscript, we will review known and possible risk factors for male breast cancer, as well as describe the clinical patterns of the disease.
AuthorsRaina M Ferzoco, Kathryn J Ruddy
JournalCurrent oncology reports (Curr Oncol Rep) Vol. 18 Issue 1 Pg. 1 (Jan 2016) ISSN: 1534-6269 [Electronic] United States
PMID26694922 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Review)
Chemical References
  • BRCA2 Protein
  • BRCA2 protein, human
  • Biomarkers, Tumor
  • Estrogens
  • Steroid 17-alpha-Hydroxylase
  • Checkpoint Kinase 2
  • CHEK2 protein, human
Topics
  • Age Factors
  • Aged
  • BRCA2 Protein (genetics)
  • Biomarkers, Tumor (genetics)
  • Breast Neoplasms, Male (epidemiology, etiology, genetics)
  • Checkpoint Kinase 2 (genetics)
  • Environmental Exposure
  • Estrogens (metabolism)
  • Genetic Predisposition to Disease
  • Hamartoma Syndrome, Multiple (complications, epidemiology)
  • Humans
  • Klinefelter Syndrome (complications, epidemiology)
  • Male
  • Mutation
  • Risk Factors
  • Steroid 17-alpha-Hydroxylase (genetics)

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