Abstract |
Henoch-Schönlein purpura nephritis (HSPN) is one of the most common types of chronic glomerulonephritis in children; however, there have been few reports on the pathogenesis and management of grade VI HSPN. We present the case of a 6-year-old boy with grade VI HSPN accompanied by severe nephrotic syndrome and hypocomplementaemia. Immunohistological studies revealed profound glomerular accumulation of CD45- and CD68-positive inflammatory cells. Moreover, some cells expressed the proliferating marker proliferating cell nuclear antigen. His proteinuria and general oedema persisted despite repeated high-dose steroid therapy; however, these clinical symptoms immediately improved after beginning treatment with cyclophosphamide (CyP). Grade VI HSPN was successfully treated with steroids and immunosuppressants. Among immunosuppressive drugs, CyP was considered the most effective.
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Authors | Masahiro Kaneko, Yohei Ikezumi, Takeshi Yamada, Hiroya Hasegawa, Utako Kaneko, Akihiko Saitoh |
Journal | Nephrology (Carlton, Vic.)
(Nephrology (Carlton))
Vol. 21
Issue 1
Pg. 68-71
(Jan 2016)
ISSN: 1440-1797 [Electronic] Australia |
PMID | 26693846
(Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2015 Asian Pacific Society of Nephrology. |
Chemical References |
- Glucocorticoids
- Immunosuppressive Agents
- Cyclophosphamide
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Topics |
- Biopsy
- Cell Proliferation
(drug effects)
- Child
- Cyclophosphamide
(therapeutic use)
- Drug Therapy, Combination
- Fluorescent Antibody Technique
- Glomerulonephritis, Membranoproliferative
(diagnosis, drug therapy, immunology)
- Glucocorticoids
(therapeutic use)
- Humans
- IgA Vasculitis
(diagnosis, drug therapy, immunology)
- Immunosuppressive Agents
(therapeutic use)
- Kidney
(drug effects, immunology, pathology)
- Leukocytes
(drug effects, immunology, pathology)
- Male
- Nephrotic Syndrome
(drug therapy, immunology)
- Severity of Illness Index
- Treatment Outcome
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