Multicenter trial of cadexomer iodine to treat venous stasis ulcer.

Abstract

In a crossover study designed to judge the efficacy of the topical polymeric starch iodophore, cadexomer iodine, in accelerating the healing of venous stasis ulcers, 75 patients were prospectively randomly assigned to receive either cadexomer iodine or standard treatment. The control treatment consisted of a standard saline wet-to-dry compressive dressing. The patients improved with either treatment: ulcers healed more than twice as rapidly using cadexomer iodine (n = 38) as with standard therapy (n = 37) (P = .0025). Ulcers treated with cadexomer iodine showed trends toward less pain, exudate, pus, and debris, and a more rapid development of granulation tissue. Twelve patients crossed over from control treatment to the use of cadexomer iodine because of a failure to heal, but no patients switched to control therapy from the use of cadexomer iodine (P = .01). Except for occasional mild local burning in wounds treated with cadexomer iodine, no adverse effects were noted with either regimen.

• Authors: G A Holloway Jr, K H Johansen, R W Barnes, G E Pierce
• Journal: The Western journal of medicine (West J Med) Vol. 151 Issue 1 Pg. 35-8 (Jul 1989) ISSN: 0093-0415 [Print] United States
• PMID: 2669345 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Iodine Compounds
• Iodophors
• cadexomer iodine
• Iodine

Topics

• Adult
• Aged
• Aged, 80 and over
• Female
• Humans
• Iodine (therapeutic use)
• Iodine Compounds
• Iodophors
• Male
• Microspheres
• Middle Aged
• Multicenter Studies as Topic
• Prospective Studies
• Random Allocation
• Varicose Ulcer