Multiorgan WU Polyomavirus Infection in Bone Marrow Transplant Recipient.

Abstract

WU polyomavirus (WUPyV) was detected in a bone marrow transplant recipient with severe acute respiratory distress syndrome who died in 2001. Crystalline lattices of polyomavirus-like particles were observed in the patient's lung by electron microscopy. WUPyV was detected in the lung and other tissues by real-time quantitative PCR and identified in the lung and trachea by immunohistochemistry. A subset of WUPyV-positive cells in the lung had morphologic features of macrophages. Although the role of WUPyV as a human pathogen remains unclear, these results clearly demonstrate evidence for infection of respiratory tract tissues in this patient.

• Authors: Erica A Siebrasse, Nang L Nguyen, Melisa J Willby, Dean D Erdman, Marilyn A Menegus, David Wang
• Journal: Emerging infectious diseases (Emerg Infect Dis) Vol. 22 Issue 1 Pg. 24-31 (Jan 2016) ISSN: 1080-6059 [Electronic] United States
• PMID: 26691850 (Publication Type: Case Reports, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)

Topics

• Bone Marrow Transplantation
• Child, Preschool
• Female
• Humans
• Lung (virology)
• Polyomavirus (isolation & purification)
• Polyomavirus Infections (diagnosis)
• Respiratory Tract Infections (virology)
• Transplant Recipients