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Sex Steroid and Gonadotropin Treatment in Male Delayed Puberty.

Abstract
Male delayed puberty is common, affecting up to 3% of the population. Management of patients with pubertal delay is dependent on the underlying cause. The main differential diagnoses of delayed puberty in males include constitutional delay of growth and puberty (CDGP), idiopathic hypogonadotropic hypogonadism and hypergonadotropic hypogonadism. Treatment of isolated CDGP involves expectant observation or short courses of low-dose sex steroid supplementation. More complex and involved management is required in males with hypogonadism to achieve both development of secondary sexual characteristics and to maximise the potential for fertility. This review will cover the options for management involving androgen or gonadotropin therapy, with discussion of benefits, limitations and specific considerations of the different treatment options.
AuthorsSasha Howard, Leo Dunkel
JournalEndocrine development (Endocr Dev) Vol. 29 Pg. 185-97 ( 2016) ISSN: 1662-2979 [Electronic] Switzerland
PMID26680579 (Publication Type: Journal Article, Review)
Copyright© 2016 S. Karger AG, Basel.
Chemical References
  • Gonadal Steroid Hormones
  • Gonadotropins
Topics
  • Adolescent
  • Gonadal Steroid Hormones (therapeutic use)
  • Gonadotropins (therapeutic use)
  • Humans
  • Male
  • Puberty, Delayed (diagnosis, drug therapy)

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