Abstract | BACKGROUND: METHODS: The anti- cancer activity of flavone, apigenin and luteolin was investigated using the MTS assay. Apoptosis was analyzed by Hoechst 33342 staining, flow cytometry and western blot. Cell migration was determined using the culture inserts and xCELLigence real-time cell analyzer instrument equipped with a CIM-plate 16. Real-time quantitative PCR and western blot were used to determine the signaling pathway elicited by flavone, apigenin and luteolin. RESULTS: CONCLUSION:
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Authors | Chia-Hung Lin, Ching-Yao Chang, Kuan-Rong Lee, Hui-Ju Lin, Ter-Hsin Chen, Lei Wan |
Journal | BMC cancer
(BMC Cancer)
Vol. 15
Pg. 958
(Dec 16 2015)
ISSN: 1471-2407 [Electronic] England |
PMID | 26675309
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antineoplastic Agents, Phytogenic
- FOXO3 protein, human
- Flavones
- Forkhead Box Protein O3
- Forkhead Transcription Factors
- Apigenin
- Proto-Oncogene Proteins c-akt
- Luteolin
- flavone
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Topics |
- Antineoplastic Agents, Phytogenic
(pharmacology)
- Apigenin
(pharmacology)
- Apoptosis
(drug effects)
- Blotting, Western
- Breast Neoplasms
(pathology)
- Cell Cycle
(drug effects)
- Cell Line, Tumor
- Cell Proliferation
(drug effects)
- Female
- Flavones
(pharmacology)
- Flow Cytometry
- Forkhead Box Protein O3
- Forkhead Transcription Factors
(metabolism)
- Humans
- Luteolin
(pharmacology)
- Proto-Oncogene Proteins c-akt
(metabolism)
- Real-Time Polymerase Chain Reaction
- Signal Transduction
(drug effects)
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