Abstract | BACKGROUND: AIM: MATERIALS AND METHODS: The study population was comprised of 50 ischemic stroke patients and 50 healthy controls. The serum PON1 and ARE activities were measured spectrophotometrically by using paraoxon and phenylacetate as substrate respectively by Eckerson method. Serum lipid was measured using routine biochemical method. RESULTS: The normality of the distribution of the parameters are assessed by Shapiro-Wilk test. Two sample t-test is applied for hypothesis testing. The serum PONI and arylesterase ARE decreased significantly in ischemic stroke patients (p<0.001). The PON1 was positively correlated with HDL. CONCLUSION: This study strongly suggests that the estimation of HDL-C associated PON1 enzyme gives valuable information for prediction of risk of ischemic stroke due to cerebrovascular thromboembolism. The result shows that PON1 and ARE could be considered as a risk factors for ischemic stroke.
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Authors | Seema Sanjay Chawhan, Mukund R Mogarekar, Reena V Wagh, Rajkumar R Das, Sanjay S Pramanik, Sanjay M Sonune, Sanjay M Chawhan |
Journal | Journal of clinical and diagnostic research : JCDR
(J Clin Diagn Res)
Vol. 9
Issue 11
Pg. BC01-3
(Nov 2015)
ISSN: 2249-782X [Print] India |
PMID | 26673997
(Publication Type: Journal Article)
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