Two New Cyclic Depsipeptides from the Endophytic Fungus Fusarium sp.

Two new cyclic depsipeptides, W493 C (1) and D (2), along with two known derivatives W493 A (3) and B (4) were obtained from the endophytic fungus Fusarium sp. isolated from the Mangrove plant Ceriops tagal. The structures of the new compounds were determined on the basis of one- and two dimensional NMR and high-resolution mass spectroscopic data. The absolute configurations of the amino acid residues of 1 and 2 were confirmed by application of Marfey's method. W493 A (3) and B (4) exhibited moderate activity against the fungus Cladosporium cladosporiodes and weak antitumor activity against the human ovarian cancer cell line A2780.
AuthorsFang Lv, Georgios Daletos, Wenhan Lin, Peter Proksch
JournalNatural product communications (Nat Prod Commun) Vol. 10 Issue 10 Pg. 1667-70 (Oct 2015) ISSN: 1934-578X [Print] United States
PMID26669100 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

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