Two New Cyclic Depsipeptides from the Endophytic Fungus Fusarium sp.

Abstract

Two new cyclic depsipeptides, W493 C (1) and D (2), along with two known derivatives W493 A (3) and B (4) were obtained from the endophytic fungus Fusarium sp. isolated from the Mangrove plant Ceriops tagal. The structures of the new compounds were determined on the basis of one- and two dimensional NMR and high-resolution mass spectroscopic data. The absolute configurations of the amino acid residues of 1 and 2 were confirmed by application of Marfey's method. W493 A (3) and B (4) exhibited moderate activity against the fungus Cladosporium cladosporiodes and weak antitumor activity against the human ovarian cancer cell line A2780.

• Authors: Fang Lv, Georgios Daletos, Wenhan Lin, Peter Proksch
• Journal: Natural product communications (Nat Prod Commun) Vol. 10 Issue 10 Pg. 1667-70 (Oct 2015) ISSN: 1934-578X [Print] United States
• PMID: 26669100 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)