[Expression of phosphofructokinase 1 protein and it's enzyme activity on nasopharyngeal carcinoma].

Abstract

OBJECTIVE:

The aim of this study is to investigate the expression of phosphofructokinase 1 and it's enzyme activity in nasopharyngeal carcinoma biopsy samples.

METHOD:

Sixty-one biopsy samples were detected, including 41 tissues from patients with nasopharyngeal carcinoma as experimental group and 20 tissues from patients with chronic nasopharyngitis as control group. Phosphofructokinase 1 protein was detected by Western blot and it's enzyme activity was detected.

RESULT:

It was observed that the expression levels of phosphofructokinase 1 protein and it's enzyme activities in the experimental group were higher than that in the control group (P < 0.01). In the experimental group, the expression levels of phosphofructokinase 1 protein and it's enzyme activities in patients with lymph node metastasis were higher than that in patients without lymph node metastasis (P < 0.01).

CONCLUSION:

Phosphofructokinase 1 may be a marker in occurrence and metastasis of nasopharyngeal carcinoma.

• Authors: Shuo Li, Haiyu Hong, Zhengde Du, Fei Liu, Qiong Yang, Chunsheng Gao
• Journal: Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery (Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi) Vol. 29 Issue 16 Pg. 1455-7 (Aug 2015) ISSN: 2096-7993 [Print] China
• PMID: 26665455 (Publication Type: Journal Article)

Chemical References

• Biomarkers, Tumor
• Phosphofructokinase-1

Topics

• Biomarkers, Tumor (metabolism)
• Biopsy
• Carcinoma
• Case-Control Studies
• Humans
• Lymphatic Metastasis
• Nasopharyngeal Carcinoma
• Nasopharyngeal Neoplasms (enzymology, pathology)
• Nasopharyngitis
• Phosphofructokinase-1 (metabolism)