Abstract |
Human herpes virus-8 (HHV-8)-associated Castleman's disease (CD) is a rare non-cancerous B-cell lymphoproliferative disorder in human immunodeficiency virus (HIV)-positive patients. We report a case of HHV-8-associated CD in an HIV-positive patient with a previous history of Kaposi's sarcoma (KS). The patient presented with progressive splenomegaly and diffuse lymphadenopathy, which can be seen in multicentric CD, KS, and HIV-associated lymphoma. There are no reliable clinical or imaging features to differentiate these diseases. Lymph node biopsy confirmed HHV-8-associated CD and excluded KS and lymphoma. Due to differences in treatment options and prognosis between the three etiologies, it is important for radiologists to include HHV-8-associated CD in the differential diagnosis when encountering HIV-positive patients that present with diffuse lymphadenopathy.
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Authors | Guan Huang, Gavin Low |
Journal | Journal of clinical imaging science
(J Clin Imaging Sci)
Vol. 5
Pg. 59
( 2015)
ISSN: 2156-7514 [Print] United States |
PMID | 26664776
(Publication Type: Case Reports)
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