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In vitro activity of Ro 23-9424, ceftazidime, and eight other newer beta-lactams against 100 gram-positive blood culture isolates.

Abstract
One hundred Gram-positive bacteremia organisms from five important genus groups were tested against 10 newer beta-lactams. Ceftazidime was significantly less active (50% of strains at less than or equal to 8 micrograms/ml) compared to other cephalosporins. The penems (FCE-22101 and HRE-664) and imipenem were each superior to the cephalosporins with 92-93% inhibition of strains. A novel fused co-drug of fleroxacin and desacetyl-cefotaxime, Ro 23-9424, was 100% effective against these Gram-positive pathogens at less than or equal to 8 micrograms/ml. Several of these compounds should receive consideration for clinical trials for empiric therapy among neutropenic patient infections where Gram-positive pathogens may be more prevalent.
AuthorsR N Jones, A L Barry
JournalDiagnostic microbiology and infectious disease (Diagn Microbiol Infect Dis) 1989 Mar-Apr Vol. 12 Issue 2 Pg. 143-7 ISSN: 0732-8893 [Print] United States
PMID2666014 (Publication Type: Journal Article)
Chemical References
  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Fluoroquinolones
  • Ro-23-9424
  • Ciprofloxacin
  • Ceftazidime
  • Cefotaxime
  • Fleroxacin
Topics
  • Anti-Bacterial Agents (pharmacology)
  • Anti-Infective Agents (pharmacology)
  • Cefotaxime (analogs & derivatives, pharmacology)
  • Ceftazidime (pharmacology)
  • Ciprofloxacin (analogs & derivatives, pharmacology)
  • Fleroxacin (analogs & derivatives)
  • Fluoroquinolones
  • Gram-Positive Bacteria (drug effects, isolation & purification)
  • Humans
  • Microbial Sensitivity Tests
  • Sepsis (microbiology)

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