Abstract | BACKGROUND: METHODS: All ischemic stroke patients registered in the Norwegian Stroke Research Registry (NORSTROKE) as part of the ongoing Bergen NORSTROKE study were included. Blood samples were obtained on admission. Stroke etiology was determined by the Trial of Org 10172 in Acute Stroke Treatment (TOAST) criteria, and the severity of stroke was defined according to the National Institute of Health Stroke Scale score. Information about cancer disease after stroke was obtained from patient medical records and The Cancer Registry of Norway. RESULTS: From a total of 1,282 ischemic stroke patients with no history of cancer, 55 (4.3%) patients were diagnosed with cancer after stroke. The median time from stroke onset to cancer diagnosis was 14.0 months (interquartile range 6.2-24.5). Twenty-three (41.8%) patients were diagnosed with cancer within 1 year and 13 (23.6%) within 6 months. The most common cancer type was lung cancer (19.0%). By Cox regression analysis, cancer after stroke was associated with elevated D-dimer levels on admittance (p < 0.001), age (p = 0.01) and smoking (p = 0.04). CONCLUSIONS:
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Authors | Henriette Aurora Selvik, Lars Thomassen, Anna Therese Bjerkreim, Halvor Næss |
Journal | Cerebrovascular diseases extra
(Cerebrovasc Dis Extra)
2015 Sep-Dec
Vol. 5
Issue 3
Pg. 107-13
ISSN: 1664-5456 [Electronic] Switzerland |
PMID | 26648966
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Fibrin Fibrinogen Degradation Products
- fibrin fragment D
- C-Reactive Protein
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Topics |
- Aged
- Aged, 80 and over
- Brain Ischemia
(blood, epidemiology)
- C-Reactive Protein
(metabolism)
- Female
- Fibrin Fibrinogen Degradation Products
(metabolism)
- Follow-Up Studies
- Humans
- Inflammation
(epidemiology)
- Male
- Middle Aged
- Neoplasms
(blood, epidemiology)
- Norway
(epidemiology)
- Prospective Studies
- Registries
- Risk Factors
- Severity of Illness Index
- Stroke
(blood, epidemiology)
- Thrombophilia
(blood, epidemiology)
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