Abstract | BACKGROUND: METHODS: This study was a randomized, open-label, and parallel-group trial consisted of a 12-months treatment period in non-dialysis CKD patients with alubuminuria and dyslipidemia. Twenty eight patients were randomly assigned either to receive diet counseling alone ( diet therapy group) or diet counseling plus pitavastatin (diet-plus- statin therapy group), to achieve the LDL-cholesterol ( LDL-C) target of <100 mg/dl. RESULTS: The statin treatment by pitavastatin was well tolerated in all of the patients without any significant adverse events and the average dose of pitavastatin was 1.0 ± 0.0 mg daily after treatment. After the 12-months treatment period, LDL-C was significantly lower in the diet-plus- statin therapy group compared with the diet therapy group (diet vs diet-plus- statin: LDL-C, 126 ± 5 vs 83 ± 4 mg/dL, P < 0.001). On the other hand, the diet-plus- statin therapy did not significantly reduce albuminuria or delay the decline in eGFR compared with the diet therapy, and there was no relationship between the change in LDL-C and the change in eGFR or albuminuria. However, diet therapy as well as diet-plus- statin therapy exerted similar lowering effects on the pentosidine levels ( diet therapy group, baseline vs 12 months: 40 ± 4 vs 24 ± 3 ng/mL, P = 0.001; diet-plus- statin therapy, 46 ± 7 vs 34 ± 6 ng/mL, P = 0.008). Furthermore, the results of multivariate regression analysis indicated that the change in pentosidine was a significant contributor to the change in eGFR (β = -0.536, P = 0.011). CONCLUSIONS:
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Authors | Masato Ohsawa, Kouichi Tamura, Hiromichi Wakui, Tomohiko Kanaoka, Kengo Azushima, Kazushi Uneda, Sona Haku, Ryu Kobayashi, Kohji Ohki, Kotaro Haruhara, Sho Kinguchi, Yoshiyuki Toya, Satoshi Umemura |
Journal | Lipids in health and disease
(Lipids Health Dis)
Vol. 14
Pg. 161
(Dec 09 2015)
ISSN: 1476-511X [Electronic] England |
PMID | 26645467
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anticholesteremic Agents
- Cholesterol, HDL
- Cholesterol, LDL
- Glycation End Products, Advanced
- Quinolines
- Triglycerides
- Arginine
- pentosidine
- Lysine
- pitavastatin
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Topics |
- Aged
- Albuminuria
(blood, diet therapy, drug therapy, pathology)
- Anticholesteremic Agents
(therapeutic use)
- Arginine
(analogs & derivatives, antagonists & inhibitors, blood)
- Cholesterol, HDL
(blood)
- Cholesterol, LDL
(antagonists & inhibitors, blood)
- Diet
(methods)
- Dyslipidemias
(blood, diet therapy, drug therapy, pathology)
- Female
- Glomerular Filtration Rate
- Glycation End Products, Advanced
(antagonists & inhibitors, blood)
- Humans
- Lysine
(analogs & derivatives, antagonists & inhibitors, blood)
- Male
- Middle Aged
- Oxidative Stress
(drug effects)
- Quinolines
(therapeutic use)
- Renal Insufficiency, Chronic
(blood, diet therapy, drug therapy, pathology)
- Triglycerides
(blood)
- Vascular Stiffness
(drug effects)
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