Abstract | OBJECTIVE: METHODS: A cross-sectional, prospective study in an 8-month period was done at the University affiliated referral cardiovascular center. The Naranjo probability scale and World Health Organization criteria for severity of ADRs were used for assessing the ADRs. The linear regression and logistic regression tests were used to evaluate the correlation between ADRs and risk factors. FINDINGS: The all 20 patients who received reteplase during the study period were entered. The majority of patients (n = 17) experienced at least one ADR. The results showed that the incidence of ADRs was mainly associated with gender and age, and the number of ADRs was associated with the history of diabetes and taking anti-diabetic agents. The gender was the main predictor in the occurrence of ADRs (odds ratio: 32, 95% confidence interval: 1.38-737.45; P = 0.030). CONCLUSION: The results showed that gender, age, diabetes mellitus, and using of anti-diabetes medications are the risk factors associated with the incidence of ADRs by reteplase.
|
Authors | Naser Aslanabadi, Naser Safaie, Faezeh Shadfar, Mohammad Reza Taban-Sadeghi, Hossein Feizpour, Simin Ozar Mashayekhi, Hadi Hamishehkar, Naser Khezerlou Aghdam, Samaneh Dousti, Hossein Namdar, Taher Entezari-Maleki |
Journal | Journal of research in pharmacy practice
(J Res Pharm Pract)
2015 Oct-Dec
Vol. 4
Issue 4
Pg. 206-11
ISSN: 2319-9644 [Print] India |
PMID | 26645027
(Publication Type: Journal Article)
|