Multicenter Phase II Study of Nedaplatin and Irinotecan for Patients with Squamous Cell Carcinoma of the Lung: Thoracic Oncology Research Group 0910.

Abstract

Squamous cell carcinoma (SCC) of the lung is moderately responsive to anticancer drugs, but no specific chemotherapy regimens have yet been established. We conducted a multicenter phase II study of nedaplatin (NP) and irinotecan (CPT) for SCC of the lung. Fifty patients underwent 4 to 6 cycles of chemotherapy comprising of NP at 100 mg/m(2) on day 1 and CPT at 60 mg/m(2) on days 1 and 8 every 4 weeks. Twenty-seven patients received 4 to 6 cycles of chemotherapy (median=4 cycles). Major toxicities included neutropenia (46.0%), grade 3 or 4 anorexia (22.0%), febrile neutropenia (16.0%), diarrhea (12.0%), hyponatremia (12.0%), grade 4 anemia (10.0%), thrombocytopenia (10.0%) and infection (10.0%). There were no treatment-related deaths. One patient achieved a complete response and 16 a partial response, with an overall response rate of 34.0%. The median survival time was 11.8 months (95% CI=8.3-15.8 months) and the 2-year survival rate was 22.0%. In conclusion, the NP and CPT regimen is not recommend for further evaluation for patients with advanced SCC of the lung.

• Authors: Kouzo Yamada, Haruhiro Saito, Tetsuro Kondo, Shuji Murakami, Noriyuki Masuda, Michiko Yamamoto, Satoshi Igawa, Ken Katono, Yuichi Takiguchi, Shunichiro Iwasawa, Ryota Kurimoto, Hiroaki Okamoto, Tsuneo Shimokawa, Yukio Hosomi, Yusuke Takagi, Kazuma Kishi, Mari Ohba, Fumihiro Oshita, Koshiro Watanabe
• Journal: Anticancer research (Anticancer Res) Vol. 35 Issue 12 Pg. 6705-11 (Dec 2015) ISSN: 1791-7530 [Electronic] Greece
• PMID: 26637886 (Publication Type: Clinical Trial, Phase II, Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
• Copyright: Copyright© 2015 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.

Chemical References

• Antineoplastic Agents
• Organoplatinum Compounds
• Irinotecan
• nedaplatin
• Camptothecin

Topics

• Adult
• Aged
• Antineoplastic Agents (administration & dosage, therapeutic use)
• Camptothecin (administration & dosage, analogs & derivatives, therapeutic use)
• Carcinoma, Squamous Cell (drug therapy, pathology)
• Female
• Humans
• Irinotecan
• Lung Neoplasms (drug therapy, pathology)
• Male
• Middle Aged
• Organoplatinum Compounds (administration & dosage, therapeutic use)