Extracellular Vesicles as Biomarkers and Therapeutic Targets in Breast Cancer.

Abstract

Cancer-derived extracellular vesicles (EVs) contain various cancer-associated molecules, such as mutated or overexpressed oncoproteins, glycoproteins, mRNAs, various non-coding RNAs and DNA fragments. They have been shown to propagate phenotypic traits, such as drug resistance, increased proliferation rate, invasiveness and stemness across cancer cells and to mediate cancer-induced immunosuppression. Therefore, cancer-derived EVs have gained increasing attention as cancer biomarkers and therapeutic targets. Unlike circulating tumor cells they are highly abundant in biofluids and, on the contrary to single-molecule circulating biomarkers, they protect their molecular cargo against degradation and may carry molecular signatures associated with specific phenotypes. Herein, we summarize studies investigating EVs as biomarkers in breast cancer and propose scenarios for various clinical applications of EV-based biomarkers in the management of breast cancer. Furthermore, we provide an overview of recent findings regarding the cancer-promoting effects of breast cancer-derived EVs and discuss opportunities for blocking EV-mediated signaling as a therapeutic strategy for breast cancer.

• Authors: Lilite Sadovska, Jānis Eglītis, Aija Linē
• Journal: Anticancer research (Anticancer Res) Vol. 35 Issue 12 Pg. 6379-90 (Dec 2015) ISSN: 1791-7530 [Electronic] Greece
• PMID: 26637847 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
• Copyright: Copyright© 2015 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.

Chemical References

• Biomarkers, Tumor

Topics

• Biomarkers, Tumor (metabolism)
• Breast Neoplasms (metabolism, pathology)
• Extracellular Vesicles (metabolism)
• Female
• Humans