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[Thrombotic thrombocytopenic purpura (Moschcowitz syndrome) in a patient with EPH gestosis. The pathophysiologic principle of HELLP syndrome? On the question of the identity of the HELLP syndrome with thrombotic thrombocytopenic purpura].

Abstract
Case history of a patient is reported who developed signs of preeclampsia in 28th week of her first gravidity. Within one day severe haemolysis and diffuse haemorrhage occurred and an emergency section was performed. Subsequently, supported respiration became necessary because of diffuse infiltrations of the lung. Laboratory data then were conclusive for a thrombotic thrombocytopenic purpura (Moschcowitz's disease) and therefore the patient was subjected to plasma exchange during seven days: this measure induced rapid and full clinical and laboratory remission. The case history is discussed on the background of the pertinent literature and the special perspective of a pathophysiological identity between the two syndromes: HELLP (haemolysis, elevated liver enzymes, low platelets) and Moschcowitz's disease (thrombotic thrombocytopenic purpura); this seems to be of special interest for an adequate therapy by plasma exchange.
AuthorsH J Staiger, O Fettig, H Theml
JournalGeburtshilfe und Frauenheilkunde (Geburtshilfe Frauenheilkd) Vol. 49 Issue 6 Pg. 597-600 (Jun 1989) ISSN: 0016-5751 [Print] Germany
Vernacular TitleThrombotische thrombozytopenische Purpura (Moschcowitz-Syndrom) bei einer Patientin mit EPH-Gestose. Die pathophysiologische Grundlage des HELLP-Syndroms? Zur Frage der Identität des HELLP-Syndroms mit der TTP.
PMID2663622 (Publication Type: Case Reports, English Abstract, Journal Article)
Chemical References
  • Blood Coagulation Factors
  • Platelet Activating Factor
  • Epoprostenol
Topics
  • Adult
  • Blood Coagulation Factors (physiology)
  • Blood Platelets (physiology)
  • Endothelium, Vascular (physiopathology)
  • Epoprostenol (physiology)
  • Female
  • Humans
  • Plasma Exchange
  • Platelet Activating Factor
  • Platelet Aggregation
  • Platelet Count
  • Pre-Eclampsia (physiopathology, therapy)
  • Pregnancy
  • Purpura, Thrombotic Thrombocytopenic (physiopathology, therapy)
  • Risk Factors
  • Syndrome

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